# FAQs

FAQs are listed below.

## Who Can Deposit Data in ChEMBL ?

Deposition of bioactivity data to ChEMBL is largely by invitation. However, if you have data sets that you think will add value to ChEMBL, then please contact us by email: chembl-help@ebi.ac.uk

## Who are the main depositors ?

The current list of ChEMBL sources can be found on the [ChEMBL Interface Documentation](https://chembl.gitbook.io/chembl-interface-documentation/frequently-asked-questions/chembl-data-questions).

## Why can't we accept V3000 molfiles?

The InChI binaries we use currently do not accept V3000 molfiles, and so we cannot accept V3000 molfiles as we need an InChI Key for ChEMBL.

## When should I use ACTIVITY\_PROPERTIES and ACTIVITY\_SUPP?  What is the difference?

The ACTIVITY\_PROPERTY file is utilised where there is a single experimental result in the ACTIVITY file, but the value(s) quoted can or should be qualified with another parameter.  Such additional information is often useful in assessing the mechanism behind the result, or the quality or reliability of the reported main value.

Examples include:

* Independent variables in the assay which may have been systematically changed in order to assess their influence on the ACTIVITY VALUE (e.g. dose of test substance).
* Calculated values relating to the ACTIVITY VALUE if considered particularly useful in assessing the quality of the ACTIVITY VALUE (e.g. the slope of an IC50 curve).

ACTIVITY\_SUPP is utilised for bulk storage of raw data relating to ACTIVITY values, including both data used directly to calculate the ACTIVITY value, and also miscellaneous data from the same experiment, not used in this calculation, but which may be of interest to the specialist user.

Examples include:

* Individual percentage inhibition points on a curve where an IC50 value has been quoted in the ACTIVITY file.
* Additional observations on the experimental animals from which data was assessed (e.g. Kidney cyst formation).
