Linking supplementary files through Depositor-Defined IDs

While more basic data can be described using compound, assay and reference IDs (CIDX, AIDX and RIDX), additional identifiers are required to link more complex data, shown in the table below:

*IDX	Description	Primary File
ACT_ID	ACTivity ID	ACTIVITY
TEOID	TEst Occasion ID	ACTIVITY
REGID	REcord Grouping ID	ACTIVITY_SUPP
SAMID	Supplementary Activity Mapping ID	ACTIVITY_SUPP

A SAMID (Single Measurement ID) uniquely identifies a single data point in ACTIVITY_SUPP	One individual measurement at one compound, dose, time point and in one entity (animal, plate well etc). So biological replicates (animals) have differing SAMIDs.
A REGID (Regimen ID) groups different measurements for the same entity and conditions	E.g. All measurements for hematology, clinical chemistry, organ weight AND pathology observed for one animal at the same compound, dose & time point.
A TEOID (Test Occasion ID) groups different ACTIVITY measurements for the same experimental conditions	E.g. All measurements for the same compound, dose, time point for all biological replicates ie across five different animals.
An ACT_ID can define an ACTIVITY record as the average measurement for a group of SAMIDs	E.g. All the bilirubin measurements for multiple animals with the same TEOID.

Identifiers present in the files link data at different levels

An example of organism-based in vivo data

An example of plate-based in vitro data