ACTION_TYPE valid names

ACTION_TYPE	DESCRIPTION	PARENT_TYPE
ACTIVATOR	Positively effects the normal functioning of the protein e.g., activation of an enzyme or cleaving a clotting protein precursor	POSITIVE MODULATOR
AGONIST	Binds to and activates a receptor, often mimicking the effect of the endogenous ligand	POSITIVE MODULATOR
ALLOSTERIC ANTAGONIST	Binds to a receptor at an allosteric site and prevents activation by a positive allosteric modulator at that site	NEGATIVE MODULATOR
ANTAGONIST	Binds to a receptor and prevents activation by an agonist through competing for the binding site	NEGATIVE MODULATOR
ANTISENSE INHIBITOR	Prevents translation of a complementary mRNA sequence through binding and targeting it for degradation	NEGATIVE MODULATOR
BINDING AGENT	Binds to a substance such as a cell surface antigen, targetting a drug to that location, but not necessarily affecting the functioning of the substance itself	OTHER
BLOCKER	Negatively effects the normal functioning of an ion channel e.g., prevents or reduces transport of ions through the channel	NEGATIVE MODULATOR
CHELATING AGENT	Binds to a metal, reducing its availability for further interactions	OTHER
CROSS-LINKING AGENT	Induces cross-linking of proteins or nucleic acids	OTHER
DEGRADER	Binds to or antagonizes a receptor, leading to its degradation	NEGATIVE MODULATOR
DISRUPTING AGENT	Destabilises or disrupts a protein complex, macromolecular assembly, cell membrane etc	OTHER
EXOGENOUS PROTEIN	Protein from an exogenous source acts as a substitute or supplement for a specific protein which is absent or has reduced function in affected patients'	POSITIVE MODULATOR
HYDROLYTIC ENZYME	Hydrolyses a substrate through enzymatic reaction	OTHER
INHIBITOR	Negatively effects (inhibits) the normal functioning of the protein e.g., prevention of enzymatic reaction or activation of downstream pathway	NEGATIVE MODULATOR
INVERSE AGONIST	Binds to and inactivates a receptor	NEGATIVE MODULATOR
METHYLATING AGENT	Methylates or participates in methylation (e.g., through donation of a methyl group) of a substrate molecule	OTHER
MODULATOR	Effects the normal functioning of a protein in some way e.g., mixed agonist/antagonist or unclear whether action is positive or negative	OTHER
NEGATIVE ALLOSTERIC MODULATOR	Reduces or prevents the action of the endogenous ligand of a receptor through binding to a site distinct from that ligand (non-competitive inhibition)	NEGATIVE MODULATOR
NEGATIVE MODULATOR	Negatively effects the normal functioning of a protein e.g., receptor antagonist, inverse agonist or negative allosteric modulator	NEGATIVE MODULATOR
OPENER	Positively effects the normal functioning of an ion channel e.g., facilitates transport of ions through the channel	POSITIVE MODULATOR
OTHER	Other action type, not clearly postively or negatively affecting the normal functioning of a protein e.g., chelation of substances, hydrolysis of substrate	OTHER
OXIDATIVE ENZYME	Oxidises a substrate through enzymatic reaction	OTHER
PARTIAL AGONIST	Binds to and only partially activates a receptor (relative to the response to a full agonist)	POSITIVE MODULATOR
POSITIVE ALLOSTERIC MODULATOR	Enhances the action of the endogenous ligand of a receptor through binding to a site distinct from that ligand	POSITIVE MODULATOR
POSITIVE MODULATOR	Positively effects the normal functioning of a protein e.g., receptor agonist, positive allosteric modulator, ion channel activator	POSITIVE MODULATOR
PROTEOLYTIC ENZYME	Hydrolyses a protein substrate through enzymatic reaction	OTHER
REDUCING AGENT	Modifies a substrate via a reduction reaction	OTHER
RELEASING AGENT	Reverses the normal functioning of a transporter, causing release of the substrate, rather than uptake	NEGATIVE MODULATOR
RNAI INHIBITOR	Prevents translation of mRNA through binding and targeting it for destruction (e.g., siRNA)	NEGATIVE MODULATOR
SEQUESTERING AGENT	Binds to a substance such as a drug, toxin or metabolite reducing its availability for further interactions	OTHER
STABILISER	Increases the conformational stability of a protein or complex	OTHER
SUBSTRATE	Carried by a transporter, possibly competing with the natural substrate for transport	OTHER
VACCINE ANTIGEN	Delivers an antigen and promotes an immune response against the antigen e.g. activating the immune system towards cancer-specific biomarkers	OTHER